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Cytoreduction and sequential resection: A hope for unresectable primary liver cancer
Author(s) -
Tang ZhaoYou,
Yu YeQin,
Zhou XinDa,
Ma ZengChen,
Lu JiZhen,
Liu KangDa,
Lin ZhiYing,
Yang BingHui,
Fan Zhen,
Hou Zhen,
Zhang Ming
Publication year - 1991
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930470107
Subject(s) - medicine , radioimmunotherapy , surgery , radiation therapy , chemotherapy , resection , retrospective cohort study , survival rate , monoclonal antibody , antibody , immunology
For decades, unresectable primary liver cancer (PLC) determined by operation was incurable. However, a retrospective study of 24 years' materials with unresectable PLC indicated that 5‐year survival of unresectable PLC has increased from 0% in 1966‐1977 (n = 137) to 16.9% in 1978‐1989 (n = 345). This encouraging improvement was mainly a result of cytoreduction therapy followed by sequential resection. Multimodality combination treatment with hepatic artery ligation, plus hepatic artery infusion with chemotherapy, plus radioimmunotherapy (or radiotherapy) yielded the highest sequential resection rate (30.6%) and 5‐year survival (28.0%) as compared with double combination and single modality treatment. The 5‐year survival of 33 patients receiving sequential resection after cytoreduction therapy was 63.2%. It is suggested that cytoreduction and sequential resection might offer a hope for surgically verified unresectable PLC.