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Immunohistochemical analysis of plasminogen activator expression in human colorectal carcinomas: Correlation with CEA distribution and tumor cell kinetics
Author(s) -
Kawanishi Hiroshi,
Tanaka Kanji,
Takai Souichirou,
Takada Hideho,
Yamamura Manabu,
Hioki Koshirou,
Nagura Hiroshi,
Yamamoto Masakatsu
Publication year - 1991
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930460408
Subject(s) - carcinoembryonic antigen , immunohistochemistry , colorectal cancer , plasminogen activator , adenocarcinoma , cancer research , pathology , medicine , cancer , microbiology and biotechnology , biology
Fifty cases of colorectal adenocarcinoma were immunohistochemically examined for the relationship between distribution of plasminogen activators (PAS) and the degree of differentiation of cancer cells as reflected by carcinoembryonic antigen (CEA) expression as well as tumor cell kinetics. The A chain of urokinase‐type PA (u‐PA‐A) was mainly observed in the apical portions of highly differentiated cancer cells. Increased expression and change in localization to the cytoplasm were found with progressive dedifferentiation. The numbers of DNA polymerase α (pol. α) positive cancer cells also increased in line with u‐PA‐A expression. The B chain of u‐PA (u‐PA‐B), and the A and B chains of tissue‐type PA (t‐PA‐A and ‐B) did not show similar alteration. The present findings suggest that the distribution of u‐PA‐A in colorectal carcinoma tissues, the degree of tumor differentiation, and the proliferation kinetics of cancer cells are closely related.