Premium
Lugol stain for intraoperative determination of the proximal surgical margin of the esophagus
Author(s) -
Sugimachi Keizo,
Tsutsui Shinichi,
Kitamura Kaoru,
Morita Masaru,
Mori Masaki,
Kuwano Hiroyuki
Publication year - 1991
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930460404
Subject(s) - medicine , esophagus , stain , margin (machine learning) , surgical margin , surgery , radiology , general surgery , resection , pathology , staining , machine learning , computer science
An adequate proximal surgical margin is difficult to determine particularly in cases of esophageal carcinoma with surrounding intraepithelial invasion. We report here readily facilitated intraoperative approaches for detection of the exact margin of carcinomatous invasion of the esophagus. The resected specimen of the esophagus is incised longitudinally and placed in a 1% Lugol bath for 2–3 minutes. The normal squamous epithelium includes glycogen that interacts with the iodine of Lugol's solution and the normal epithelium of the esophagus becomes a uniform greenish‐brown. A squamous cell carcinoma does not include glycogen, hence is not stained with this solution and a clear identification is feasible. Thus, a carcinomatous infiltration not recognizable in routine examinations becomes macroscopically visible when Lugol's solution is used.