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Characterization of cellular infiltrates in the rat urinary bladder following BCG and thiotepa intravesical therapy
Author(s) -
Shaw Michael,
McKiel Charles F.,
Ray Vera,
Rubenstein Marvin,
Guinan Patrick
Publication year - 1991
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930460112
Subject(s) - thiotepa , medicine , urinary system , urinary bladder , peripheral blood mononuclear cell , bcg vaccine , infiltration (hvac) , urology , pathology , immunology , chemotherapy , surgery , cyclophosphamide , in vitro , vaccination , biology , biochemistry , physics , thermodynamics
We examined rat urinary bladders following intravesical administration of BCG and thiotepa. BCG administration resulted in a relatively greater increase in the mucosal infiltration of mononuclear cells relative to polymorphonuclear cells ( P <0.01) compared to the thiotepa treated bladders. This finding suggests that the mode of action of the therapeutic effects of these agents may be different. These results may also suggest that the mechanism of action of BCG might be immunologic in nature.