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Immune‐competent cells of regional lymph nodes in colorectal cancer patients: II. Immunohistochemical analysis of leu‐7 + cells
Author(s) -
Adachi Wataru,
Usuda Nobuteru,
Sugenoya Akira,
Iida Futoshi
Publication year - 1990
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930450406
Subject(s) - germinal center , lymph , medicine , lymph node , colorectal cancer , immunohistochemistry , immune system , population , pathology , cancer cell , cancer , cancer research , immunology , antibody , b cell , environmental health
Distribution of Leu‐7 + cells in cancer tissues and regional lymph nodes was immunohistochemically examined to estimate the role of NK cells in colorectal cancer patients. Leu‐7 + cells were rarely observed both in the primary and distant metastatic lesions, but the number of these cells was large in the germinal center of the lymph nodes. Studies of Leu‐7 + cell population in the lymph node indicated that intermediate nodes in n0 and n1 groups showed significantly higher values than those in the control group. Comparative study of the population in identical patients revealed a significantly higher rate in the intermediate nodes than in the paracolic nodes both in n0 and n1 groups. These data suggest that Leu‐7 + cells might be related to the defense mechanism of regional lymph nodes against tumor.