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Small cell carcinoma of the pancreas and biliary tract
Author(s) -
Motojima Koichi,
Furui Junichiro,
Terada Masazumi,
Shiogama Toshiaki,
Kohara Norihiro,
Tsunoda Tsukasa,
Tsuchiya Ryoichi
Publication year - 1990
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930450306
Subject(s) - anaplastic carcinoma , medicine , pathology , pancreas , adenocarcinoma , carcinoma , metaplasia , biliary tract , chemotherapy , cancer
Four cases of anaplastic carcinoma of the pancreas or biliary tract were studied clinicopathologically and immunohistochemically. All four cases were intermediate cell type and contained a minimum amount of microscopic foci of differentiated glandular adenocarcinoma. Argyrophilic tumor cells were not seen in any of the four tumors. Immunohistochemically, no tumor was positive for hormonal products, but all tumors were positive for epithelial markers. These findings suggest that the anaplastic carcinoma are not derived from argyrophilic cells, but rather from adenocarcinomas which have the potential for anaplastic metaplasia. The long‐term survival of one patient emphasized the importance of chemotherapy in the treatment of small cell carcinoma of the pancreas and biliary tract.