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Use of rhodamine 123 in the treatment of the pollard iii rat prostate adenocarcinoma
Author(s) -
Arcadi John A.
Publication year - 1990
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930440209
Subject(s) - medicine , adenocarcinoma , rhodamine 123 , prostate , rhodamine , prostate adenocarcinoma , urology , pathology , cancer , biology , drug resistance , fluorescence , physics , quantum mechanics , multiple drug resistance , microbiology and biotechnology
Abstract Significant destruction of the Pollard III rat prostate adenocarcinoma was achieved by treatment with rhodamine 123 at a dosage of 15 mg/kg every other day for 33 to 38 days. Injection of tumor remnants into untreated animals produced no tumor regrowth. Our data have demonstrated rhodamine 123 to be a significant drug for the management of the very aggressive Pollard III tumor.