Premium
Central venous catheter complications in sarcoma patients receiving adjuvant chemotherapy
Author(s) -
Israel Robert J.,
Magill Cordon B.,
Brennan Murray F.
Publication year - 1990
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930440208
Subject(s) - medicine , bolus (digestion) , catheter , chemotherapy , surgery , central venous catheter , soft tissue sarcoma , silastic , randomized controlled trial , sarcoma , prospective cohort study , complication , adjuvant , anesthesia , soft tissue , pathology
As part of a prospective randomized study in patients with high grade soft tissue sarcoma (STS), 47 patients received post‐operative adjuvant Adriamycin. The method of administration was randomized to intravenous bolus (B) or to continuous 72 hour infusion (CI) via a Silastic right atrial catheter. Both groups received 60 mg/m 2 every 3 weeks. There were nine hospital admissions for treatment related complications in four of the 26 CI patients compared to none in the 21 B patients ( P = 0.03). All of the admissions related to complications involving the central venous catheter (CVC). This apparent increased risk for hospital admission secondary to treatment related complications in patients treated with CI must be considered in the planning of future therapeutic trials.