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Immunohistochemical analysis of the relationship between CEA localization and mononuclear cell infiltration in human colorectal carcinoma
Author(s) -
Tanaka Kanji,
Nagura Hiroshi,
Hamada Yoshinori,
Yamamura Manabu,
Hioki Koshirou,
Watanabe Keiichi,
Yamamoto Masakatsu
Publication year - 1990
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930430210
Subject(s) - infiltration (hvac) , stroma , pathology , immunohistochemistry , peripheral blood mononuclear cell , colorectal cancer , adenocarcinoma , immune system , cytoplasm , medicine , carcinoma , cancer cell , carcinoembryonic antigen , biology , cancer , immunology , in vitro , microbiology and biotechnology , biochemistry , physics , thermodynamics
Thirty cases of colorectal adenocarcinoma were immunohistochemicaliy examined to clarify the relationship between the degree of differentiation of cancer cells reflected by the mode of CEA localization and the infiltration pattern of mononuclear cells in the carcinoma tissues. Leu 1 + , Leu 2a + , Leu 3a + 3b + T lymphocytes, Leu 7 + cells, and IgA‐containing plasma cells tended to be distributed more in areas where CEA was localized over the entire surface of the cancer cells or in their surrounding stroma than where CEA was located along the apical surface or within the cytoplasm. Carcinoma cells with the pattern of CEA staining at the former site were previously shown to be less differentiated than those at the latter. There were also CEA‐containing phagocytes which were often observed where T cells and IgA plasma cells had aggregated. We speculated that the dedifferentiation of cancer cells might cause the host immune response, especially the cellular immunity, in malignant lesions.