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In situ demonstration of immunological heterogeneity in vascular endothelial cells of renal cell carcinoma
Author(s) -
Kinjo Tsutomu,
Takashi Munehisa,
Miyake Koji,
Nagura Hiroshi
Publication year - 1990
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930430203
Subject(s) - medicine , renal cell carcinoma , in situ , pathology , cancer research , meteorology , physics
Abstract Phenotypic characteristics of endothelial cells of blood vessels in renal cell carcinoma were studied immunohistochemically. Vascular endothelial cells in different compartments expressed surface antigens heterogenously. Sinusoidal capillary endothelial cells adjacent to carcinoma cells shared antigens with a monocyte/macrophage subset (OKM5 +, HLA‐DR +, interleukin‐1 +), but were only faintly positive or absent for factor VIII/von Willebrand factor antigen. Endothelial cells of larger vessels in fibrous septa were OKM5‐, HLA‐DR +, interleukin‐1 +, factor VIII/von Willebrand factor antigen+. Renal cell carcinoma cells expressed HLA‐DR and HLA‐ABC antigens. These findings suggest that renal cell carcinoma cells are surrounded by blood vessels containing effector cells for immune responses, and that they have a high‐potency response to immunopotentiators.