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Functional estrogen receptors as biochemical marker for the detection of hormone‐dependent breast cancer
Author(s) -
Vij U.,
Murugesan K.,
Kapur B. M. L.,
Sarin R.,
Dhawan I. K.,
Farooq A.
Publication year - 1990
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930430105
Subject(s) - medicine , breast cancer , estrogen , estrogen receptor , hormone receptor , hormone , receptor , cancer , oncology , endocrinology
The translocatable receptors categorized as functional receptors were quantitated in a cross‐incubation study of breast cancer nuclei with receptor‐rich uterine cytosol. Data demonstrated that tumors that contained cytosolic estrogen receptor (ER) but had translocation defect might not be hormone dependent, whereas tumors with low ER but intact nuclear trans‐location step will respond to antiestrogen therapy. Cytosolic ER was estimated in 114 primary breast cancer tissues and ten metastatic axillary lymph nodes; 58% of postmenopausal and 54% of premenopausal breast cancer tissues were ER + with a cutoff value of 10 fmoles and 3 fmoles/mg protein, respectively. Of tumors in the premenopausal and postmenopausal state, 62% and 57%, respectively, were positive for nuclear ER, with a cutoff value of 10 fmoles/100 μg DNA. This study suggested that evaluation of functional ER level would reduce the number of false‐negative and false‐positive tumors.