Premium
Preoperative adjuvant chemotherapy for advanced head and neck cancer: A surgical evaluation
Author(s) -
Loré John M.,
Bonilla Juan A.,
Spaulding Monica,
Lee Keun Y.,
Kaufman Sol,
Sundquist Nan,
Smeeding Diane
Publication year - 1989
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930420503
Subject(s) - medicine , bleomycin , vincristine , chemotherapy , head and neck cancer , stage (stratigraphy) , surgery , adjuvant chemotherapy , head and neck , adjuvant , cancer , oncology , radiation therapy , cyclophosphamide , paleontology , breast cancer , biology
This presentation consists of two parts: 1) a brief account of the results of treating 94 patients with stage III (n = 24) and stage IV (n = 70) advanced head and neck cancer, primarily with two courses of preoperative adjuvant chemotherapy; and 2) an evaluation of 42 of the 94 patients consecutively treated by surgery by the senior author. It is our conclusion that preoperative chemotherapy using cisplatin, vincristine, and bleomycin can improve the compromised airway and deglutition without producing deleterious effects relative to surgical complications. Moreover, overall survival is promising and justifies continued study using organized protocols.