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Selective internal radiation (SIR) therapy for treatment of liver metastases: Measurement of response rate
Author(s) -
Gray B. N.,
Burton M. A.,
Kelleher D. K.,
Anderson J.,
Klemp P.
Publication year - 1989
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930420313
Subject(s) - medicine , carcinoembryonic antigen , selective internal radiation therapy , laparotomy , parenchyma , radiation therapy , radiology , internal radiation , dosimetry , nuclear medicine , microsphere , pathology , cancer , hepatocellular carcinoma , chemical engineering , engineering
Ten patients with liver metastases from primary tumors in the colorectum were treated with selective internal radiation (SIR) therapy. This involved the embolisation of yttrium‐90‐containing microspheres into the hepatic artery at the time of laparotomy. The microspheres were concentrated in the microvasculature of the tumour nodules by the concurrent administration of angiotensin II. The radiation dose being delivered to liver parenchyma was measured at the time of operation by use of an intraoperative radiation detection probe. All nine patients in whom the preoperative carcinoembryonic antigen (CEA) level was elevated experienced a decrease in CEA levels posttreatment. Intraoperative dosimetry confirmed the poor correlation between total radioactivity used and radiation dose received by normal liver parenchyma.