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Effects of intratumoral injection of I‐125 lododeoxyuridine on ehrlich ascites carcinoma
Author(s) -
Hong Seong Su,
Ford Edith H.,
Alfieri Alan A.,
Bravo Sergio
Publication year - 1989
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930420312
Subject(s) - saline , medicine , ascites , ehrlich ascites carcinoma , suspension (topology) , ratón , physiological saline , tumor cells , cancer research , mathematics , homotopy , pure mathematics
Intratumoral injection of I‐125 iododeoxyuridine (IUdR), saline solution, and oil suspension was investigated using Ehrlich ascites tumors in the thighs of mice. The oil suspension was more effective in tumor growth delay than was the saline solution. Single injection of the oil suspension at the dose of 12.5 μCi resulted in 21.5 days growth delay, whereas 50 μCi of the saline solution resulted in 11.5 days growth delay relative to control growth delay. At 40 days after treatment, higher radioactivities were observed in the tumor and the skin of the mice treated with the oil suspension, which represented the prolongation of I‐125 IUdR oil suspension within the tumor. No normal tissue toxicities were observed.