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Expression of epidermal growth factor receptors in four histologic cell types of lung cancer
Author(s) -
Kaseda Shizuka,
Ueda Masakazu,
Ozawa Soji,
Ishihara Tsuneo,
Abe Osahiko,
Shimizu Nobuyoshi
Publication year - 1989
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930420106
Subject(s) - epidermal growth factor , epidermal growth factor receptor , adenocarcinoma , pathology , lung cancer , cancer research , receptor , squamous carcinoma , metastasis , cancer , medicine , cell , carcinoma , small cell carcinoma , biology , genetics
Lung cancer tissues from 68 patients were examined for epidermal growth factor (EGF) receptor levels and EGF receptor gene copy numbers. Histologic cell types of these lung cancer tissues included squamous‐cell carcinoma (n = 30), adenocarcinoma (n = 28), large‐cell carcinoma (n = 4), and small‐cell carcinoma (n = 6). Tissues of squamous‐cell carcinoma exhibited exceptionally high 125 I‐EGF binding activity, and those of small‐cell carcinoma showed no EGF binding activity. Southern blot hybridization analysis revealed EGF receptor gene amplification in the squamous‐cell carcinomas with high EGF binding activity. The EGF receptor levels in squamous‐cell carcinomas and adenocarcinomas were compared with their pathological staging grouping and pathological findings, including degree of differentiation, diameter of tumor, and lymph node metastasis. However, unlike previous reports on breast and bladder cancers, there was no obvious correlation between these pathological characteristics and the EGF receptor levels of lung cancer.