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Complications of hypogastric artery cisplatin infusions
Author(s) -
Menashe David S.,
Jacobs Stephen C.
Publication year - 1989
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930410306
Subject(s) - medicine , cisplatin , anesthesia , catheter , surgery , urinary system , artery , internal iliac artery , urology , chemotherapy
In an attempt to increase the therapeutic index of Cisplatin (CDDP), 29 continuous 48 hour intra‐arterial (IA) infusions of 100–150 mg/m 2 CDDP were given to 26 patients with bulky stage T3–T4 bladder cancer. Hypogastric artery catheters were placed distal (n = 42) or proximal (n = 7) to the origin of the superior gluteal artery. Atherosclerosis (n = 5) or aneurysm (n = 2) prevented successful IA catheter placement. Catheter maintenance resulted in no bleeding or thromboembolic episodes. Urethral catheters caused two urinary tract infections. Systemic toxicity was mild with on 4/29 infusions resulting in WBC< 3,000, 3/29 infusions resulting in creatinine elevation, and 1/29 in peripheral neuropathy. Local effects of the IA CDDP included gluteal pain and ecchymosis (n = 1) and moderately disabling lower extremity neuropathies (n = 3). Systemic side effects of CDDP can be diminished by use of IA route of administration and slow continuous infusion.