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Optimal debulking following chemotherapy of advanced‐stage epithelial ovarian carcinoma
Author(s) -
Piura Benjamin,
Glezerman Marek
Publication year - 1989
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930400407
Subject(s) - laparotomy , debulking , medicine , chemotherapy , surgery , tumor debulking , stage (stratigraphy) , ovarian carcinoma , ovarian cancer , general surgery , cancer , paleontology , biology
We reviewed the records of 110 consecutive patients with advanced‐stage epithelial ovarian carcinoma treated at the Soroka Medical Center, Beer‐Sheva, Israel, from 1961‐1987. Twenty patients (18.1%) had optimal debulking at initial laparotomy, 30 patients (27.2%) had nonoptimal debulking at initial laparotomy, 20 patients (18.1%) had an “inoperable” disease at initial laparotomy, and 40 patients (36.3%) had such poorly written records that no information about the degree of resectability at initial laparotomy could be obtained. Four patients, in whom the residual tumor left at initial laparotomy had responded to chemotherapy, had a second laparotomy. In all four patients optimal debulking surgery at second laparotomy was easy to perform and was successful. The value of a second laparotomy after a few cycles of chemotherapy in order to optimally debulk the residual tumor left at initial laparotomy is discussed. It is concluded that a second attempt of debulking surgery after chemotherapy has a respectable place in the management of patients with advanced‐state epithelial ovarian carcinoma, but further research is needed.