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Limitations of flow cytometric DNA analysis for the diagnosis of bladder cancer
Author(s) -
Boileau Michel A.,
Swartz Douglas,
Schmidt Karmen L.,
Schmidt Waldemar A.
Publication year - 1989
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930400313
Subject(s) - medicine , flow cytometry , aneuploidy , bladder cancer , pathology , nuclear dna , dna , transitional cell carcinoma , cell , cancer , urology , biology , immunology , genetics , mitochondrial dna , chromosome , gene
Flow cytometric analysis was done on exfoliated urothelial cells from 11 control patients and 31 patients with transitional cell carcinoma: 9 grade I, 11 grade II, and 11 grade III. The determination of aneuploidy by DNA analysis did not provide identification of low‐grade tumor cells. Other flow cytometric parameters of cellular change such as cell size, nuclear size, nuclear/cytoplasmic ratio, or cell refractivity may provide better identification of low‐grade lesions.