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Combination chemotherapy with carboplatin and bleomycin for advanced and recurrent head and neck cancer: A phase II study
Author(s) -
GonzalezVela Jose L.,
Panasci Lawrence,
Black Martin,
Pollak Michael,
Margolese Richard
Publication year - 1988
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930390318
Subject(s) - carboplatin , medicine , bleomycin , head and neck cancer , chemotherapy , head and neck , cisplatin , cancer , oncology , surgery
Carboplatin is a platinum analogue with activity reported in head and neck cancer. We conducted a phase II trial with 14 patients who had recurrent head and neck cancer. They were treated with carboplatin 300 mg/m 2 intravenously (I.V.) and bleomycin 30 units I.V. every 4 weeks. No responses were observed in this group of patients. Dose intensity of carboplatin administration may be an important determinant of response.