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Mouse ovarian tumor cells: An experimental model for progestin‐mediated radiotherapy
Author(s) -
Blumenthal Rosalyn D.,
McLaughlin William H.,
Jordan Jerold J.,
Cryan Ellen V.,
Bloomer William D.
Publication year - 1988
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930390206
Subject(s) - medicine , receptor , in vivo , in vitro , progestin , cancer research , estrogen receptor , radiation therapy , ovarian cancer , tumor cells , estrogen , ovary , endocrinology , biology , cancer , breast cancer , biochemistry , microbiology and biotechnology
Abstract Mouse ovarian tumor (MOT) cells have been grown in C3HeB/FeJ mice as an ascites and as a subcutaneous tumor and in cell culture as a suspension. These cells contain saturable, high‐affinity, specific progesterone receptors. Estrogen receptors were not detectable in these cells. MOT cells can be used as both an in vivo and an in vitro model for progestin‐mediated radiotherapy.