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Primary malignant melanoma of the nasal cavity: A clinicopathologic study of nine cases
Author(s) -
Matias Carlos,
Corde Jose,
Soares Jorge
Publication year - 1988
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930390106
Subject(s) - medicine , nasal cavity , melanoma , pathology , immunoperoxidase , atypia , nuclear atypia , mitotic index , necrosis , immunohistochemistry , surgery , mitosis , cancer research , antibody , immunology , monoclonal antibody , biology , microbiology and biotechnology
Nine cases of primary malignant melanoma of the nasal cavity are presented. All the patients had epistaxis and nasal obstruction at admission. Gross aspect of the neoplasia showed a fungating mass located in the right nasal cavity in six cases and in the left nasal cavity in three. Eight tumors were formed by polygonal cells and one tumor by spindle cells. Melanosis of the adjacent mucosa was found in only 1 case. S‐100 protein was demonstrated by indirect immunoperoxidase in all cases. The mean survival rate was 23.8 months. Prognosis was not related to the histologic pattern, cell atypia, necrosis, pigment secretion, or mitotic index. Radiotherapy seemed to have some beneficial influence on the survival but did not influence the local recurrence and metastatic spread of the disease.