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Ornithine decarboxylase levels in the rectal mucosa of patients with colonic neoplasia
Author(s) -
Koo Harry B.,
Sigurdson Elin R.,
Daly John M.,
Berenson Mark,
Groshen Susan,
Decosse Jerome J.
Publication year - 1988
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930380407
Subject(s) - medicine , ornithine decarboxylase , biopsy , gastroenterology , colorectal cancer , intestinal mucosa , cancer , enzyme , biology , biochemistry
Ornithine decarboxylase (ODC) activity in biopsy specimens of normalappearing rectal mucosa was measured in 15 control patients, 5 patients with colon adenomas, and 11 patients with colon cancer. While women had significantly higher ODC activity than men, ODC activity was increased regardless of gender in the rectal mucosal biopsies of patients with benign or malignant colonic neoplasia compared with those of controls. The positive predictive value of ODC activity for remote colonic neoplasia was 61 % for women and 91 % for men. The results provide a rationale for long‐term studies of ODC activity in rectal mucosa as a biological marker of high risk for large bowel neoplasia.