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Prognostic significance of estrogen and progesterone receptors in stage ii breast cancer
Author(s) -
Rydén Stefan,
Fernö Mårten,
Borg Åke,
Hafström Larsolof,
Möller Torgil,
Norgren Allan
Publication year - 1988
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930370402
Subject(s) - medicine , progesterone receptor , estrogen , breast cancer , stage (stratigraphy) , oncology , estrogen receptor , gynecology , receptor , cancer , biology , paleontology
Estrogen (ER) and progesterone receptors (PgR) were evaluated in samples from primary tumors in 539 patients with stage II breast cancer participating in a randomized multicenter controlled clinical trial on adjuvant therapy. At the cut‐off points of 10 fmol ER/mg protein and 30 fmol PgR/mg protein, no significant difference in recurrence‐free survival (RFS) existed between premenopausal patients with receptor‐positive and negative tumors, respectively. After recurrence, premenopausal patients with receptor‐positive tumors had a significant longer survival than patients with receptor‐negative tumors. In postmenopausal patients not treated with adjuvant tamoxifen, no correlations between RFS and receptor status were found. Patients with ER + tumors survived longer than patients with ER–tumors. In postmenopausal patients treated with adjuvant tamoxifen, highly significant differences in RFS and in survival were observed when receptor‐positive patients were compared with receptor‐negative patients. No differences in survival after recurrence were registered among these patients.