Thermal resistance of human malignant melanoma modulated by prostaglandin E 2 | Zendy

Kern David H. | Zendy; Krag David N. | Zendy; Kauffman Gordon L. | Zendy; Morton Donald L. | Zendy; Storm F. Kristian | Zendy

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Thermal resistance of human malignant melanoma modulated by prostaglandin E 2

Author(s) -

Kern David H.,

Krag David N.,

Kauffman Gordon L.,

Morton Donald L.,

Storm F. Kristian

Publication year - 1988

Publication title -

journal of surgical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.201

H-Index - 111

eISSN - 1096-9098

pISSN - 0022-4790

DOI - 10.1002/jso.2930370117

Subject(s) - prostaglandin e2 , thymidine , melanoma , prostaglandin , cell culture , dna synthesis , dna damage , medicine , prostaglandin e , cancer research , cell , dna , microbiology and biotechnology , biochemistry , biology , genetics

The inhibition of DNA synthesis in a human malignant melanoma cell line as measured by tritiated thymidine ( 3 H‐TdR) incorporation was both time and temperature dependent. Two components of cell damage were identified: a cytostatic, temporary component from which no was observed. Thermotolerance was induced in M14 cells by sublethal heat treatment at 41°C for 1 hr. However, induction of thermotolerance was blocked by indomethacin, a prostaglandin synthetase inhibitor. Exogenous PGE 2 at concentrations up to 10 μg/ml also protected cells from heat damage. These data suggest that prostaglandin synthesis increases during heat stress and may play a role in protecting cells from thermal damage.

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