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Flow cytometric analysis for assessing the malignant potential of breast cancer
Author(s) -
Abe Rikiya,
Ueki Hamaichi
Publication year - 1987
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930360409
Subject(s) - medicine , breast cancer , metastasis , oncology , cancer , aneuploidy , stage (stratigraphy) , flow cytometry , pathology , immunology , biology , paleontology , biochemistry , chromosome , gene
Flow cytometric analysis was performed on 60 patients with breast cancer to investigate the relationship between DNA histogram and the malignant potential of breast cancer. DNA aneuploidy of breast cancer tended to increase with increasing stage and degree of nodal metastasis. The percent of cells in the S phase was significantly increased in the patients with metastasis compared to those without metastasis. Patients exhibiting percent S phase value of more than 20% showed a high frequency of metastasis even when breast tumors were small (T 1 , < 2.0 cm in diameter). Thus, flow cytometric analysis may give additional information on biological characteristics and may be useful for predicting the prognosis of breast cancer in some patients.