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Autotransplantation of colonic tumors into the colonic wall of the rat
Author(s) -
Rubio C.,
Nylander G.,
Wallin B.,
Sveander M.,
Duvander A.,
Alun M.
Publication year - 1987
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930360314
Subject(s) - medicine , autotransplantation , transverse colon , colorectal adenocarcinoma , dimethylhydrazine , transplantation , descending colon , colonic cancer , adenocarcinoma , colonic carcinoma , colorectal cancer , pathology , gastroenterology , carcinoma , rectum , cancer
Colonic tumors were induced in Sprague‐Dawley rats by weekly subcutaneous injections of 1,2 Dimethylhydrazine (DMH) for 4 months. The animals were thereafter laparotomized and a palpable tumor was transplanted into the same animal in a tumor‐free area of the transverse colon. Autotransplanted tumors were considered those tumors growing in the wall of the transverse colon, covered by intact colonic mucosa. The frequency of autotransplanted tumors was 34%. The possibility that auto‐transplantation may also occur in humans by accident, during procedures to remove a colorectal adenocarcinoma, is discussed.