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Tumor‐induced osteomalacia: Long‐term follow‐up of two patients cured by removal of their tumors
Author(s) -
Sparagana Mario
Publication year - 1987
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930360310
Subject(s) - hypophosphatemia , osteomalacia , medicine , aminoaciduria , vitamin d and neurology , rickets , endocrinology , urology , surgery , gastroenterology , urine
Two patients with mesenchymal tumors had osteomalacia associated with marked hypophosphatemia and renal phosphate wasting. Their serum calcium and parathyroid hormone levels were normal. The first patient also had aminoaciduria and glucosuria in addition to phosphaturia. Both patients were treated with very large doses of vitamin D 2 and phosphate without improvement in the osteomalacia or normalization of the serum phosphate. Complete removal of a low‐grade fibrosarcoma in the second patient and removal of an ossifying fibroma in the first patient resulted in a cure in both patients despite no further therapy with vitamin D or phosphate. The excessive aminoaciduria and glucosuria of the first patient also remitted. During a 14‐year follow‐up period, there has been no evidence of tumor recurrence, hypophosphatemia, or osteomalacia in either patient. The levels of 1,25‐dihydroxycholecalciferol remain within the normal range in both patients.