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Importance of biologic status to the postoperative prognosis of patients with stage III nonsmall cell lung cancer
Author(s) -
Nakahara Kazuya,
Monden Yasumasa,
Ohno Kiyoshi,
Fujii Yoshitaka,
Hashimoto Junpei,
Kitagawa Youichiro,
Kawashima Yasunaru
Publication year - 1987
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930360302
Subject(s) - medicine , performance status , stage (stratigraphy) , gastroenterology , lung cancer , cancer , lung , disease , oncology , paleontology , biology
Abstract The prognosis of patients with stage III nonsmall cell lung cancer was studied, with special attention to their biologic status prior to lung resection. The biologic status was estimated from the neutrophil/lymphocyte ratio in the peripheral blood, serum albumin level, and erythrocyte sedimentation rate. Among 46 patients who underwent potentially curative operations, 31 cases of biologic status A or B (more than two parameters normal) revealed 37.6% of a 5‐year survival rate, whereas there was no 5‐year survivor in 15 cases of biologic status C or D (more than two parameters abnormal). Of the 5‐year survival rate in T 3 N 0 disease of biologic status A or B, the 60% surviving (of 10 cases) was in marked contrast to the same stage disease of biologic status C or D where only 1 patient (of 10 cases) was still surviving at more than 30 months. In 30 patients with T 3 N 0 , T 3 N 1 , and T 2 N 2 diseases of biologic status A or B, where long‐term survivors were derived, the 5‐year survival rate in 30 patients of biologic status A or B was 36.6% in contrast to no long‐term survivor in the same stage diseases of biologic status C or D (n = 25). We conclude that surgical results in stage III nonsmall cell lung cancer will be beneficial in patients of biologic status A or B, but nonbeneficial in patients with the same stage of biologic status C or D.