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Proton NMR of human breast tumors: Correlation with clinical prognostic parameters
Author(s) -
Chu David Z. J.,
Yamanashi William S.,
Frazer James,
Hazlewood Carlton F.,
Gallager H. Stephen,
Boddie Arthur W.,
Martin Richard G.
Publication year - 1987
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930360102
Subject(s) - medicine , proton nmr , nuclear magnetic resonance spectroscopy , nuclear magnetic resonance , stage (stratigraphy) , proton , nuclear medicine , correlation , estrogen receptor , human breast , pathology , breast cancer , biology , cancer , physics , paleontology , geometry , mathematics , quantum mechanics
Proton NMR spectroscopy and imaging of human breast tissue have provided new methods in studying breast carcinomas. Continuous wave proton NMR spectroscopy in this study is able to discriminate breast carcinomas from normal breast tissue on the basis of the integrated area under the water and lipid peaks, width at half height of the water peak, and chemical shift of the lipid peak. In addition, the NMR parameters were correlated with the following clinical and pathologic prognostic indices: TNM tumor stage, nuclear grade, and estrogen receptor status (ER). Width at half height of the lipid peak (1/2Δlipid) correlated with tumor content and ER. Studies using higher resolution proton or phosphorus NMR spectra may separate signals that can correlate with biological information on breast neoplasms useful to the clinician. Chemical shift of the lipid peak may be used to sharpen contrast on MRI of breast tumors.