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Short‐term prophylaxis with cefuroxime in colorectal surgery for cancer
Author(s) -
Colizza S.,
De Fazio S.,
Addari A.,
Grande R.,
Cucchiara G.
Publication year - 1987
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930350412
Subject(s) - medicine , cefuroxime , group b , sepsis , surgery , colorectal cancer , antibiotic prophylaxis , group a , colorectal surgery , abdominal surgery , antibiotics , significant difference , cancer , anesthesia , microbiology and biotechnology , biology
A controlled study of short‐term prophylaxis with cefuroxime was performed on a group of 52 patients with colorectal neoplasms who underwent elective surgery. The patients were divided into two groups, A and B. Group A received the antibiotic immediately before surgery, intraincisionally and immediately after the end of operation; group B was treated only postoperatively. Each patient received a total of 5,250 mg of cefuroxime. Wound sepsis was demonstrated in 11.5% of cases of group A and 23.0% of group B (P < 0.01); another type of sepsis was observed in 34% of group A and 11.5% of group B (P < 0.001). There was no difference in the operative mortality in the two groups.