Short‐term prophylaxis with cefuroxime in colorectal surgery for cancer | Zendy

Colizza S. | Zendy; De Fazio S. | Zendy; Addari A. | Zendy; Grande R. | Zendy; Cucchiara G. | Zendy

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Short‐term prophylaxis with cefuroxime in colorectal surgery for cancer

Author(s) -

Colizza S.,

De Fazio S.,

Addari A.,

Grande R.,

Cucchiara G.

Publication year - 1987

Publication title -

journal of surgical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.201

H-Index - 111

eISSN - 1096-9098

pISSN - 0022-4790

DOI - 10.1002/jso.2930350412

Subject(s) - medicine , cefuroxime , group b , sepsis , surgery , colorectal cancer , antibiotic prophylaxis , group a , colorectal surgery , abdominal surgery , antibiotics , significant difference , cancer , anesthesia , microbiology and biotechnology , biology

A controlled study of short‐term prophylaxis with cefuroxime was performed on a group of 52 patients with colorectal neoplasms who underwent elective surgery. The patients were divided into two groups, A and B. Group A received the antibiotic immediately before surgery, intraincisionally and immediately after the end of operation; group B was treated only postoperatively. Each patient received a total of 5,250 mg of cefuroxime. Wound sepsis was demonstrated in 11.5% of cases of group A and 23.0% of group B (P < 0.01); another type of sepsis was observed in 34% of group A and 11.5% of group B (P < 0.001). There was no difference in the operative mortality in the two groups.

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