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Diabetes in pancreatectomized baboons: A model for pancreatin transplantation studies
Author(s) -
Toit Don F. Du,
Heydenrych Jacobus J.,
Louw Gawie,
Zuurmond Theuns,
Laker Lida,
Smit Ben,
Els Daniel,
Weideman André,
Davids Henry,
WolfeCoote Sonja,
Toit Lorraine Du
Publication year - 1987
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930350316
Subject(s) - medicine , pancreatectomy , insulin , diabetes mellitus , endocrinology , transplantation , plasma glucose , pancreas transplantation , total pancreatectomy , stimulation , pancreas , kidney transplantation
This study was designed to assess plasma glucose levels (PLG) and insulin release in totally pancreatectomized baboons when challenged with intravenous glucose administration (IVGTT). Ten animals ( Pupio ursinus ) were used and duodenectomy was intentionally avoided. The PLG at death was 18.0 ∓ mmol/L, and the mean K‐value within 3 days after pancreatectomy was 0.4% ∓ 0.2%, indicating a significant impairment of glucose disappearance from the blood when compared to the control animals (P < 0.01). Plasma insulin levels before and after stimulation with glucose were below the lowest level of insulin assay sensitivity. We conclude that in the primate, as in the dog, surgical pancreatectomy produced a reliable diabetic model, which is uniformly lethal if left untreated.