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Hepatic adenoma within a spindle cell carcinoma in a woman with a long history of oral contraceptives
Author(s) -
Grigsby P.,
Meyer J. S.,
Sicard G. A.,
Huggins M. B.,
Lamar D. J.,
DeschryverKecskemeti K.
Publication year - 1987
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930350307
Subject(s) - medicine , adenoma , general surgery , carcinoma , gynecology , oncology
The case of a young woman is presented who had a long history of oral contraceptive use and who was found to have a focal hepatic adenoma within a large spindle cell carcinoma of the liver. The pleomorphic tumor is positive for keratin and α 1 ‐antitrypsin by immunohistochemistry, has intracellular lumina by electron microscopy, a moderately high thymidine labeling index, and is negative for estrogen and progesterone receptors. A review of the literature concerning liver tumors occurring in young patients indicates that there is an underlying disturbance of the hormonal milieu in all instances reported. The prognosis is widely variable and unpredictable.