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Sebaceous adenocarcinoma of meibomian gland origin with targetoid intra‐nuclear inclusion
Author(s) -
Goldstein Jed,
Avinoah Ilana,
Lifshitz Tova
Publication year - 1987
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930350213
Subject(s) - medicine , chalazion (fungus) , meibomian gland , pathology , eyelid , lesion , conjunctiva , adenocarcinoma , parenchyma , anatomy , dermatology , radiology , cancer
Neoplastic proliferation of the meibomian glands is most often characterized by a tarsal tumor of the eyelid conjunctiva, having the clinical appearance of a chalazion. As such, the tumor is frequently not recognized as a neoplasm and is treated conservatively as an inflammatory lesion. A protracted clinical course combined with repeated surgical excisions typify this slow‐growing tumor of sebaceous gland cells. In addition to the usual features of polygonal cell shape, abundant cytoplasm, and numerous fat vacuoles, we describe the presence of a peculiar nuclear inclusion seen only in the parenchymal cells of this tumor, and having the appearance of concentric layers of electron‐dense material surrounding an opaque electron lucent core.