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Effect of splenectomy on treatment of lewis lung carcinoma by an immunomodulatory polysaccharide and a cytotoxic agent
Author(s) -
Michowitz Moshe,
Kopel Shoshana,
Hoenig Shoshana,
Leibovici Judith
Publication year - 1987
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930340412
Subject(s) - lewis lung carcinoma , splenectomy , medicine , spleen , cyclophosphamide , cytotoxic t cell , polysaccharide , immunotherapy , chemotherapy , lung , carcinoma , immunology , cancer research , immune system , cancer , biology , biochemistry , in vitro , metastasis
The effect of the spleen on the efficiency of chemotherapy (cyclophosphamide) and immunotherapy (the polysaccharide levan) of C57BL mice bearing the Lewis lung carcinoma was studied. The development of Lewis lung carcinoma caused a gradual splenomegaly in the C57BL mice. Splenectomy did not, however, affect tumor growth in the nontreated host. Levan induced a pronounced splenomegaly. Splenectomy reduced markedly the antitumoral effect of the polysaccharide. These results indicate that spleen elements participate in the inhibitory activity of levan. By contrast, splenectomy had no effect on the efficiency of treatment of cyclophosphamide.