Premium
Significance of the “maturation” of metastases from Wilms' tumor after therapy
Author(s) -
Omar Rawhi,
Davidian Marianna M.,
Marcus Judith R.,
Rose Judith
Publication year - 1986
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930330407
Subject(s) - medicine , radiation therapy , wilms' tumor , pathology , mesenchymal stem cell , reversion , neoplasm , radiology , phenotype , biology , biochemistry , gene
Several metastatic nodules were discovered in the lungs of a 4‐year‐old boy two years after surgical excision of Wilms' tumor with subsequent chemotheraphy and local irradiation. All these metastatic nodules were composed of differentiated mesenchymal elements similar to those encountered in the primary neoplasm. Similar “mature” metastases have been observed by pathologists in other tumors of embryonic origin. Review of available literature and clinical and experimental data supports the notion that “reversion” of malignant cells into phenotypically benign counterparts may take place spontaneously or under the influence of environmental factors. Anticancer agents (cytostatics, radiation) selectively destroy the more anaplastic cells present in a malignant tumor (or its metastatic implants), thus allowing the “benign” revertants to predominate. Although such lesions are benign‐appearing, it is recommended that they be completely excised; however, but further chemo‐ or radiotherapy may not be necessary.