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Interferon‐β treatment of metastatic prostate cancer
Author(s) -
Bulbul M. A.,
Huben R. P.,
Murphy G. P.
Publication year - 1986
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930330405
Subject(s) - medicine , chills , prostate cancer , prostate , cancer , refractory (planetary science) , oncology , interferon , alpha interferon , chemotherapy , gastroenterology , surgery , immunology , physics , astrobiology
A limited clinical trial of Interferon‐β (Human Fibroblast Interferon) in the treatment of advanced, hormone‐refractory postate cancer was conducted by the National Prostate Cancer Project (NPCP Protocol 2100). Sixteen patients with metastatic prostate cancer who had failed prior hormone therapy were entered into the study. Treatment consisted of 6 × 10 6 units of Interferon‐β intravenously three times per week for 12 weeks. Chills and fever were seen in ten of the 16 patients (62.5%), and mild hematologic toxicity occurred in four patients. No complete or partial responses were observed. Three patients had stable disease by NPCP criteria for a mean duration of 6.3 months. Progression of disease was seen in 13 of the 16 patients, eight of whom progressed during therapy. The results of this study suggest that Interferon‐β has limited efficacy in the treatment of advanced, horomone‐refractory prostate cancer.