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Radiation‐associated thyrotoxicosis
Author(s) -
Katayama Shigehiro,
Shimaoka Katsutaro,
Osman Gamal
Publication year - 1986
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930330205
Subject(s) - medicine , thyroid , antibody , anti thyroid autoantibodies , gastroenterology , radiation therapy , autoantibody , endocrinology , immunology
We studied 154 consecutive patients with a diagnosis of thyrotoxicosis seen at Roswell Park Memorial Institute from 1963 to 1982. The retrospective review of the clinical materials revealed that 23 (15%) had a previous history of therapeutic radiation for various diseases. The radiation dose ranged from several to 3600 rads to the thyroid with a mean latency of 14.2 ± 3.0 years. In 11 out of 16 patients who were tested for antithyroglobulin and antimicrosomal showed positive liters of either or both antibodies (69%). In a small number of patients, thyroid stimulating immunoglobulins were studied; long‐acting thyroid stimulators (LATS) were positive in one of six tested and thyrotrophin binding inhibitory immunoglobulins (TBII) in five of eight. The radiation‐associated thyroidal dysfunction appears to be associated with the organ‐specific autoimmune processes and could manifest as either hypo‐ or hyperfunction of the gland.