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The syndrome of inappropriate antidiuretic hormone secretion associated with induction chemotherapy for squamous cell carcinoma of the head and neck
Author(s) -
Hayes Daniel F.,
Lechan Ronald M.,
Posner Marshall R.,
Weichselbaum Ralph R.,
Miller Daniel,
Ervin Thomas J.
Publication year - 1986
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930320306
Subject(s) - medicine , antidiuretic , bleomycin , chemotherapy , hormone , head and neck , induction chemotherapy , cisplatin , basal cell , oncology , pathology , surgery
Two patients with squamous cell carcinoma of the head and neck are reported in whom the syndrome of inappropriate antidiuretic hormone (SIADH) secretion occurred transiently during the rapid cytolytic phase of tumor destruction after chemotherapy with cis‐platinum diamminedi‐chloride and bleomycin. Immunoperoxidase staining for ADH of the original biopsy specimens from both patients was negative. Possible mechanisms for and the implications of the production of SIADH in this setting are discussed.