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The demonstration of papilloma virus in cervical dysplasia and/or neoplasia
Author(s) -
Ghosh Luna,
Nadimpalli Venkat R.,
Ronan Salve G.,
Robertson Abel L.
Publication year - 1986
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930320108
Subject(s) - dysplasia , pathology , medicine , immunoperoxidase , carcinoma in situ , carcinoma , papilloma , biopsy , lesion , epithelium , antibody , immunology , monoclonal antibody
Thirty‐three random biopsy specimens of uterine cervix were studied by immunoperoxidase technique to evaluate the presence of HPV antigen in dysplastic and neoplastic cells. Four cases of mild dysplasia, nine cases of moderate to severe dysplasia, two cases of carcinoma in situ and one case of invasive carcinoma were associated with condylomatous lesions. Intranuclear dark‐brown precipitates were observed in superficial and intermediate zones of the dysplastic epithelium. Positive reaction was seen in condylomatous epithelium associated with neoplasia. No nuclear precipitates were observed in carcinoma cells, but one noncondylomatous lesion with moderate dysplasia showed positive intranuclear staining. These preliminary findings suggest that papilloma viruses may play a role in the development of human cervical neoplasias.