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Histiocytoid carcinoma: A variant of breast cancer
Author(s) -
Eisenberg Burton L.,
Bacnall James W.,
Harding Clarke T.
Publication year - 1986
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930310410
Subject(s) - medicine , pathology , breast carcinoma , breast cancer , carcinoma , invasive lobular carcinoma , immunoperoxidase , cancer , apocrine , lobular carcinoma , oncology , invasive ductal carcinoma , ductal carcinoma , monoclonal antibody , antibody , immunology
The history of a patient presenting with metachronous bilateral breast cancer displaying histiocytoid features is reviewed. Although regional metastases were noted, this patient has not demonstrated an aggressive systemic disease pattern. In the past, histiocytoid breast cancer has been classified as either a lipid‐rich carcinoma or as a variant of lobular carcinoma. However, histiocytoid carcinoma should be considered a distinct entity. Unlike the lipid‐rich carcinomas, this tumor stained strongly for mucin. Immunoperoxidase staining indicated strong positivity for CEA and negative staining for alpha‐lactabumin. There is suggestive evidence of a relationship between histiocytoid breast carcinoma and breast cancers of apocrine origin. Controversy remains and further evaluation is needed to elucidate the histiogenesis and biological potential of this neoplasm.