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Monitoring the histogenesis of colonic tumors in the Sprague‐Dawley rat
Author(s) -
Rubio C. A.,
Nylander G.,
Wahlin B.,
Sveander M.,
Duvander A.,
Alun M.L.
Publication year - 1986
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930310319
Subject(s) - histogenesis , dimethylhydrazine , medicine , adenocarcinoma , adenoma , pathology , carcinogen , body weight , lymphatic system , gastroenterology , physiology , biology , cancer , colorectal cancer , immunohistochemistry , genetics
A total of 306 male Sprague‐Dawley rats, injected with dimethylhydrazine (DMH), dose 21 mg/kg body weight s.c, were investigated. Of the 109 rats receiving the dose once only, seven colonic adenocarcinomas developed; all seven (100%) were seen to originate in discrete lymphoid patches. Of the 97 rats treated with one dose/week for 3 months, only 6% of the 50 adenocarcinomas developed in discrete lymphoid patches, while 46% were seen to originate in a pre‐existing adenoma. Of the remaining 100 rats, receiving one dose/week for 6 months, only 3.5% of the 57 adenocarcinomas arose from discrete lymphoid patches; 43.9% arose from a pre‐existing adenoma. Thus, the histogenesis of adenocarcinomas at our laboratory appears to be dose‐dependent. Experiments are therefore being designed to monitor in detail the events of these two histogenetically different adenocarcinomas in the colonic mucosa in our animal model.