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Cell surface antigens in squamous cell carcinoma of the oral cavity
Author(s) -
Das S. N.,
Khan. N.,
Khanna Sushila,
Gupta S.
Publication year - 1986
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930310305
Subject(s) - medicine , lymph , pathology , basal cell , oral cavity , pathological , cancer , stage (stratigraphy) , epidermoid carcinoma , carcinoma , squamous carcinoma , cell , anaplastic carcinoma , oncology , biology , paleontology , orthodontics , genetics
The ABH isoantigen was investigated in 80 patients with squamous cell carcinoma of the oral cavity and in‐their 46 affected lymph nodes. Isoantigen deletion shows a characteristic pattern of benign to malignant transformation of oral cancer. Total loss of isoantigen was found in anaplastic tumours, in metastatic lymph nodes and in the majority of advanced stage tumours. Total loss of isoantigen in metastatic lymph nodes indicates a frequent discharge of isoantigen‐negative metastatic cells from the primary tumours to the lymph nodes and the regional organs. It seems that with the recent techniques a prospective observation of ABH isoantigen added to other pathological and clinical findings could be of prognostic significance in patients with squamous cell carcinoma of the oral cavity.