Premium
Low‐dose (diagnostic‐like) X‐ray as a cocarcinogen in mouse colon carcinoma
Author(s) -
Weinerman B. H.,
Orr K. B.,
Lu L.,
Rogers A.
Publication year - 1986
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930310304
Subject(s) - medicine , carcinoma , colon carcinoma , colorectal cancer , nuclear medicine , oncology , radiology , cancer
To test the hypothesis that low‐dose (diagnostic‐like) radiation may play the part of a cocarcinogen in inflammatory bowel disease, we used four groups of BALB/C mice, (a control, dimethylhydrazine, dimethylhydrazine plus low‐dose radiation, and low‐dose radiation). We found no protective or carcinogen effects of the radiation in combination with dimethylhydrazine compared to dimethylhydrazine alone. This type of negative experimental finding is important in that individuals with inflammatory bowel disease have many diagnostic x‐rays throughout life.