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Demonstration of cutaneous doxorubicin extravasation by rhodamine‐filtered fluorescence microscopy
Author(s) -
Duray Paul Harrison,
Cuono Charles B.,
Madri Joseph A.
Publication year - 1986
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930310104
Subject(s) - extravasation , medicine , fluorescence microscope , rhodamine , microscopy , fluorescence , doxorubicin , pathology , chemotherapy , optics , surgery , physics
Accidental extravasation of the widely used antineoplastic anthracycline doxorubicin (adriamycin) is capable of causing serious and on‐going skin and soft tissue necrosis leading to loss of limb function. The only effective cure has been the complete surgical excision of drug‐contaminated tissue. Surgical excisions preparatory to skin grafting have often underestimated the extent of drug infiltration into tissue. Using an experimental technique utilizing the drug's natural property of red fluorescence, we were able to effect complete surgical excision by rhodamine fluorescence microscopy in frozen sections of resected skin.