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In vitro antibiotic activity of 11 beta‐lactam antibiotics in a cancer center
Author(s) -
Landoy Zvi,
Rotstein Coleman,
Surgalla Michael J.,
Botzer Robert,
Fitzpatrick John E.,
Blumenson Leslie E.
Publication year - 1985
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930300108
Subject(s) - mezlocillin , antibiotics , cephalosporin , microbiology and biotechnology , medicine , aminoglycoside , klebsiella pneumoniae , lactam , pseudomonas aeruginosa , bacteria , biology , chemistry , escherichia coli , stereochemistry , biochemistry , genetics , gene , piperacillin
Two‐thousand, five‐hundred and twenty‐four bacterial isolates were tested against 11 new beta‐lactam antibiotics in a prospective study conducted in a cancer center. E. coli, P. aeruginosa , and K. pneumoniae were the most common gram‐negative organisms isolated, while S. aureus and Entero ‐ cocccus were the most common organisms among the gram‐positive. The new cephalosporins were more active than the semisynthetic penicillins against E. coli, P. aeruginosa , and K. pneumoniae (p<0.001). Mezlocillin had better activity than the other semisynthetic penicillins against most of the gram‐negative organisms as well as the enterococci. As a result, mezlocillin was preferred as a beta‐lactam agent to be employed with an aminoglycoside as empiric antibiotics for febrile patients with neoplasia.