The effects of hyperthermia on vascular permeability in experimental liver metastasis | Zendy

Lefor Alan T. | Zendy; Makohon Stefania | Zendy; Ackerman Norman B. | Zendy

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The effects of hyperthermia on vascular permeability in experimental liver metastasis

Author(s) -

Lefor Alan T.,

Makohon Stefania,

Ackerman Norman B.

Publication year - 1985

Publication title -

journal of surgical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.201

H-Index - 111

eISSN - 1096-9098

pISSN - 0022-4790

DOI - 10.1002/jso.2930280412

Subject(s) - evans blue , hyperthermia , vascular permeability , medicine , microcirculation , permeability (electromagnetism) , pathology , metastasis , chemistry , cancer , biochemistry , membrane

The effects of hyperthermia on vascular permeability in Walker carcino‐sarcomas and host liver tissue were studied in Sprague‐Dawley rats. A quantitative Evans blue technique was used to measure permeability. With tumors heated to 40° C, a nontherapeutic level, no changes in tumor vascular permeability as compared to control levels were noted. However, with tumors heated to 43° C, within the therapeutic range of hyperthermia, significant rises in tumor vascular permeability occurred. Permeability was increased at both time periods studied, 30 minutes and 6 hours after hyperthermia and injection of Evans blue. These changes are similar to those seen after physical damage from freeze‐thaw. It is likely that alterations in tumor microcirculation play a role in the therapeutic effect of intense hyperthermia.

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