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Mitomycin C extravasation ulcers
Author(s) -
Khanna A. K.,
Khanna Anuradha,
Asthana A. K.,
Misra M. K.
Publication year - 1985
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930280207
Subject(s) - extravasation , medicine , mitomycin c , surgery , chemotherapy , anesthesia , pathology
In a four‐year period, eight patients with mitomycin C extravasation ulcers were encountered. Mitomycin C extravasation produces a painful indolent ulcer that does not have any tendency to heal. If extravasation of the drug is recognized, infusion should be stopped immediately, and the site of infusion should be changed. The ulcers should be excised, and primary closure is recommended; if it is not possible then the defect is covered by a partial thickness skin graft.