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The mortality rate from lung metastases in animals inhaling nitrogen dioxide (NO 2 )
Author(s) -
Richters Arnis,
Richters Valda,
Alley Wayne P.
Publication year - 1985
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930280115
Subject(s) - medicine , nitrogen dioxide , inhalation , lung cancer , lung , room air distribution , pollutant , stage (stratigraphy) , physiology , mortality rate , toxicology , anesthesia , pathology , surgery , biology , chemistry , physics , organic chemistry , ecology , paleontology , thermodynamics
A study was carried out to determine the interrelationship between the inhalation of nitrogen dioxide (0.4 ± 0.50 ppm), lung metastases development from circulating cancer cells, and death rate from such metastases. C57 BL/6J mice were used in these experiments. Animals were divided into control and NO 2 ‐exposed groups, and were exposed to filtered air and 0.4 ppm of NO 2 , respectively. Following 12 weeks of exposure, all animals were infused intravenously with syngeneic, viable B16 melanoma cells. The results indicate that a subpopulation of NO 2 ‐exposed animals showed a significant increase in mortality rate during the early part of the experiment. The interpretation is that animals especially sensitive to the NO 2 insult developed extensive metastases at an early stage. The question raised is whether or not the progression of human cancer is influenced by the inhalation of noxious pollutants in the ambient atmosphere.