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Malignant neoplasm of mixed mesenchymal and neuroepithelial origin (ectomesenchymoma) of thigh
Author(s) -
Shuangshoti Samruay,
Kasantikul Vira,
Suwangool Pongsepeera,
Chittmittrapap Soottiporn
Publication year - 1984
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930270317
Subject(s) - medicine , pathology , neuroepithelial cell , neoplasm , neural crest , chondrosarcoma , oligodendroglioma , glioma , neuroblastoma , neural tube , astrocytoma , anatomy , biology , cancer research , embryo , genetics , stem cell , neural stem cell , microbiology and biotechnology , cell culture
A 49‐year‐old man had a malignant soft tissue tumor of the right thigh with metastasis to the femoral region and lower quadrant of the anterior abdominal wall on the right side and the left supraclavicular lymph nodes. The neoplasm showed features of chondrosarcoma and primitive neuroectodermal tumor (combined neuroblastoma, ependymoma, astrocytoma. and oligodendroglioma). The gliomatous part of the mixed tumor was confirmed by identification of the glial fibrillary acidic protein (GFAP). The diverse cellular population suggests a tumor origin from the ectomesenchymal remnant of the neural crest. The mesenchymal component of the neural crest would differentiate into the chondrosarcoma and the neuroectodermal component into the primitive neuroectodermal neoplasm. These various neoplastic elements, then, would form a neoplasm of mixed mesenchymal and neuroepithelial origin or an ectomesenchymoma.