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Plasma histaminase activity in carcinoma of the cervix—Its clinical significance
Author(s) -
Birdi Ashwi,
Gupta Saroj,
Gambhir S. S.
Publication year - 1984
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930250416
Subject(s) - medicine , cervix , gastroenterology , plasma levels , basal cell , radiation therapy , oncology , urology , cancer
Plasma histaminase activity has been estimated in 79 patients with squamous cell carcinoma of the cervix. The mean plasma histaminase value is significantly higher in patients than in controls (P < 0.001). The plasma histaminase activity falls significantly following radiotherapy (P < 0.001). Pretreatment plasma histaminase values do not show any correlation with clinical stages and the posttreatment values decline significantly but remain higher in clinical stages III and IV than in stages I and II. The increased plasma histaminase activity also reflects the degree of differentiation within the tumor. Further it is noted that the plasma histaminase value is inversely proportional to the radiation response. It is suggested that estimation of plasma histaminase activity can serve as an important marker in assessing the treatment response and monitoring the course of treatment.